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目的 探讨参桂胶囊对冠心病心绞痛的作用。方法 采用冠状动脉结扎法、垂体后叶素诱发心肌缺血法、离体心脏冠脉灌流法、86Rb测定心肌营养血流量法、肌酸磷酸激酶测定法观察参桂胶囊对冠心病心绞痛的作用。结果 参桂胶囊能够缩小结扎大鼠冠状动脉引起的急性心肌梗塞范围 ,减轻舌静脉注射垂体后叶素诱发的大鼠心电图ST段及T波的改变 ,增加离体豚鼠心脏冠脉血流量 ,降低大鼠血清中肌酸磷酸激酶值 ,增强小鼠心肌对 86Rb的摄取 ,增加心肌营养血流量。结论 参桂胶囊对冠心病心绞痛有比较强的作用。
Objective To investigate the effect of Shen Gui Capsule on angina pectoris of coronary heart disease. Methods The coronary artery ligation method, pituitrin-induced myocardial ischemia, isolated heart coronary perfusion, 86Rb determination of myocardial nutrient flow, creatine phosphokinase assay were used to observe the effect of Shen Gui Capsule on coronary heart disease angina pectoris. Results Shen Gui capsule can reduce the scope of acute myocardial infarction induced by ligation of rat coronary artery, reduce the change of ST segment and T wave induced by tongue venule in rats induced by lingual vein injection, and increase the coronary blood flow of isolated guinea pig heart. Creatine phosphokinase in rat serum enhanced myocardial uptake of 86Rb and increased myocardial nutrient blood flow. Conclusion Shen Gui capsule has a stronger effect on coronary heart disease angina.