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目的系统评价喜炎平注射液治疗小儿秋季腹泻的临床疗效方法检索国内2010~2015年间公开发表的有关喜炎平注射液治疗小儿秋季腹泻的文献,采用Jadad量表对文献质量进行评价,对纳入文献的数据资料采用Rev Man5.2软件进行统计分析。结果共纳入文献20篇,涉及病例数3296例,其中15篇文献为喜炎平注射液对比利巴韦林注射液治疗小儿秋季腹泻,6篇文献为常规治疗加用喜炎平注射液对比单纯常规措施治疗小儿秋季腹泻。Rev Man5.2异质性检验分别为:df=14,p=0.97,I~2=0%;df=5,p=0.65,I~2=0%,均采用固定效应模型分析总有效率结果:喜炎平注射液对比利巴韦林注射液:OR=4.02,95%CI为(2.78,5.80)整体效果检验Z=7.42,P<0.00001;常规治疗加用喜炎平注射液对比单纯常规措施治疗:OR=5.86,95%CI为(3.70,9.29)整体效果检验Z=7.52,P<0.00001。结论常规治疗基础上加用喜炎平注射液对比常规治疗加用利巴韦林注射液或单纯常规措施治疗小儿秋季腹泻具有更好的临床疗效。
Objective To systematically evaluate the clinical efficacy of Xiyanping injection in the treatment of infantile autumn diarrhea.Methods The literature about the treatment of autumnal diarrhea in children from 2010 to 2015 in China was searched and the quality of the literature was evaluated by Jadad scale Literature data using Rev Man5.2 software for statistical analysis. Results A total of 20 articles were included in the literature, involving 3296 cases. Among them, 15 articles were Xiyanping injection versus Ribavirin injection for the treatment of infantile autumn diarrhea. Six articles were compared with conventional treatment with Xiyanping injection Routine measures to treat children with autumn diarrhea. Rev Man5.2 heterogeneity tests were: df = 14, p = 0.97, I ~ 2 = 0%; df = 5, p = 0.65, I ~ 2 = 0%, were used fixed effect model analysis of the total effective rate Results: Xiyanping contrast ribavirin injection: OR = 4.02,95% CI (2.78,5.80) overall effect test Z = 7.42, P <0.00001; conventional treatment plus Xiyanping injection contrast simple Routine measures of treatment: OR = 5.86, 95% CI (3.70,9.29) Overall effect test Z = 7.52, P <0.00001. Conclusion Conventional treatment with Xiyanping injection compared with conventional treatment plus ribavirin injection or simple routine treatment of pediatric fall diarrhea has a better clinical efficacy.