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目的:研究肠易激综合征(irritable bowel syndrome,IBS)患者回肠末端及升结肠黏膜组织中白介素-6(interleukin-6,IL-6)、白介素-23(interleukin-23,IL-23)的表达。方法:70例腹泻型和40例便秘型IBS患者及30例健康人,用免疫组化法测定回肠末端及升结肠肠黏膜中IL-6及IL-23水平。结果:IL-6及IL-23在腹泻型及便秘型IBS患者回肠末端及升结肠的表达均高于对照组(P<0.05)。结论:IBS患者回肠及升结肠黏膜炎性细胞因子表达水平升高,可能与IBS症状有关。
OBJECTIVE: To study the effects of interleukin-6 (IL-6), interleukin-23 (IL-23) in the terminal ileum and ascending colon mucosa of patients with irritable bowel syndrome (IBS) expression. Methods: 70 cases of diarrhea and 40 cases of constipation IBS patients and 30 healthy people, the immunohistochemical method was used to determine the levels of IL-6 and IL-23 in the terminal and ascending colon of the ileum. Results: The expression of IL-6 and IL-23 in the terminal ileum and ascending colon of IBS patients with diarrhea and constipation was higher than that of the control group (P <0.05). Conclusion: IBS patients with elevated expression of inflammatory cytokines in the ileum and ascending colon mucosa may be related to IBS symptoms.