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目的探讨纳屈酮治疗大鼠急性出血坏死性胰腺炎内毒素血症的效果．方法应用５０ｇ／Ｌ牛磺胆酸钠逆行胰胆管注射诱发大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）模型，观察对照组、ＡＨＮＰ组及纳屈酮（ＮＴＸ）治疗组６，１２，２４ｈ大鼠血浆淀粉酶、内毒素（ＥＴ）及胰腺组织光镜和电镜下病理改变，并统计３组大鼠４８ｈ存活率结果ＡＨＮＰ组较对照组：于６，１２，２４ｈ时点血浆淀粉酶（２４０７±５１２，２８７２±４１３，３４１５±５９４，ｎｍｏｌ／ｓ）、ＥＴ（４５±２３，９３±１２，１６０±３５，ＥＵ／Ｌ）升高；ＮＴＸ组较ＡＨＮＰ组：血浆淀粉酶（１５３２±５６７，１８９５±５９４，２４８３±８１８，ｎｍｏｌ／ｓ）、ＥＴ（２８±３，２１±８，６９±９，ＥＵ／Ｌ）下降；而且光镜及电镜下，ＮＴＸ组胰腺腺胞及间质病理损害减轻．结论ＮＴＸ可通过降低ＡＨＮＰ大鼠血浆ＥＴ，而改善胰腺病理损害，降低其死亡率
Objective To investigate the effect of naltrexone on acute hemorrhagic necrotizing pancreatitis in rats with endotoxemia. Methods Acute hemorrhagic necrotizing pancreatitis (AHNP) model was induced by injection of 50g / L sodium taurocholate into pancreaticobiliary ducts in rats. The rats in control group, AHNP group and NTX group were observed for 6, 12 and 24 hours Plasma amylase, endotoxin (ET) and pancreatic tissue under light microscope and electron microscope pathological changes, and statistics of 3 groups of rats 48h survival rate results AHNP group compared with the control group: at 6,12,24h plasma amylase (2407 ± (P <0.05). Compared with AHNP group, plasma amylase (1532 ± 567, nmol / s) and ET (45 ± 23,93 ± 12,160 ± 35, EU / 1895 ± 594,2483 ± 818 nmol / s), ET (28 ± 3,21 ± 8,69 ± 9, EU / L) decreased. Under the light microscope and electron microscope, Reduce. Conclusion NTX can ameliorate pancreatic pathological damage and reduce its mortality by decreasing ET in plasma of AHNP rats