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过氧化物酶体增殖因子活化受体(PeroxisomeProliferatoractivatedreceptors,PPARs)属于Ⅱ型核受体超家族成员,是一种配体激活转录因子,通过与位于某些基因上游的特异的DNA反应元件相互作用而调控基因表达。PPARγ在胶质瘤、垂体腺瘤中表达丰富。噻唑二酮类化合物(Thiazolidinediones,TZDs)是PPARγ的人工合成配体,可能通过抑制PPARγ的表达来抑制肿瘤的增殖和生长。
Peroxisome proliferator-activated receptors (PPARs), members of the type II nuclear receptor superfamily, are ligand-activated transcription factors that interact with specific DNA-responsive elements located upstream of certain genes Regulate gene expression. PPARγ is abundant in glioma and pituitary adenoma. Thiazolidinediones (TZDs) are synthetic ligands of PPARγ, which may inhibit tumor proliferation and growth by inhibiting the expression of PPARγ.