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目的比较卡维地洛与美托洛尔治疗慢性充血性心力衰竭(CHF)疗效。方法 93例患者随机分为两组,卡维地洛组47例,美托洛尔组46例,治疗12个月,观察两组治疗前后心率、血压、心功能、超声心动图变化。结果总有效率卡维地洛组95.7%,美托洛尔组80.4%,治疗后收缩压卡维地洛组(120.2±15.3)mm Hg,美托洛尔组(127.1±16.8)mm Hg;舒张压卡维地洛组(81.2±10.2)mm Hg,美托洛尔组(87.3±8.5)mm Hg;心率卡维地洛组(78.5±8.2)次/m in,美托洛尔组(66.5±8.2)次/m in。治疗后左窒射血分数(LVEF)卡维地洛组(42.6±3.3)%,美托洛尔组(38.4±3.8)%;左窒舒张末期内径(LVEDD)卡维地洛组(54.8±4.7)mm,美托洛尔组(56.9±4.6)mm。结论卡维地洛及美托洛尔均能明显改善心功能,但卡维地洛的疗效更为显著。
Objective To compare the efficacy of carvedilol and metoprolol in the treatment of chronic congestive heart failure (CHF). Methods Ninety-three patients were randomly divided into two groups: 47 patients in the carvedilol group and 46 patients in the metoprolol group for 12 months. The changes of heart rate, blood pressure, cardiac function and echocardiography were observed before and after treatment. Results The total effective rate was 95.7% in the carvedilol group, 80.4% in the metoprolol group, and 120.2 ± 15.3 mm Hg in the systolic blood pressure and 127.1 ± 16.8 mm Hg in the metoprolol group after treatment. (81.2 ± 10.2) mm Hg in diastolic blood pressure group, (87.3 ± 8.5) mm Hg in metoprolol group, and 78.5 ± 8.2 heart / week in metoprolol group 66.5 ± 8.2) times / m in. After treatment, left ventricular ejection fraction (LVEF) was significantly higher in the carvedilol group (42.6 ± 3.3%) and metoprolol group (38.4 ± 3.8%); left ventricular end diastolic diameter (LVEDD) 4.7) mm, metoprolol group (56.9 ± 4.6) mm. Conclusion Carvedilol and metoprolol can significantly improve cardiac function, but the effect of carvedilol more significant.