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目的探讨新疆多民族食管癌患者癌组织及癌旁组织中p53蛋白表达情况及其临床意义。方法采用免疫组织化学En Vision法检测214例维吾尔族、汉族、哈萨克族食管癌患者癌组织以及100例癌旁正常组织中p53蛋白表达情况,并结合不同民族、肿瘤分化程度等临床病理特点进行分析。结果 44.3%的食管癌病例检测到p53蛋白的阳性表达,p53蛋白在癌组织的阳性表达率高于癌旁正常组织,差异有统计学意义(P<0.05)。维吾尔族、汉族、哈萨克族食管癌组织中p53蛋白阳性表达率分别为45.6%、38.4%、49.3%,各民族间差异无统计学意义(P>0.05),p53在不同性别、分化程度和淋巴结转移之间的阳性表达差异有统计学意义(P<0.05)。患者的预后与淋巴结转移、脉管侵犯、浸润程度状况有关(P<0.05)。结论 p53基因在新疆不同民族食管癌的发生、发展及淋巴结转移中可能有重要作用,可作为预测转移潜能的参考指标。
Objective To investigate the expression of p53 protein and its clinical significance in cancerous tissue and paracancerous tissues of multi-ethnic esophageal cancer patients in Xinjiang. Methods Immunohistochemical En Vision method was used to detect the expression of p53 protein in 214 cases of Uygur, Han and Kazak esophageal cancer tissues and 100 cases of adjacent normal tissues. The clinical and pathological features of different ethnic groups and tumor differentiation were analyzed . Results The positive expression rate of p53 protein was detected in 44.3% of esophageal cancer cases, and the positive rate of p53 protein in cancer tissue was higher than that in adjacent normal tissues (P <0.05). The positive rates of p53 protein expression in Uygur, Han and Kazak esophageal cancer tissues were 45.6%, 38.4% and 49.3%, respectively. There was no significant difference among all ethnic groups (P> 0.05). The expression of p53 in different sex, differentiation and lymph node The positive expression difference between metastasis was statistically significant (P <0.05). The prognosis of patients with lymph node metastasis, vascular invasion, infiltration of the degree of status (P <0.05). Conclusion The p53 gene may play an important role in the occurrence, development and lymph node metastasis of esophageal cancer in different ethnic groups in Xinjiang and may serve as a reference index for predicting the metastatic potential.