用中枢神经组织进行皮下免疫,容易使多数哺乳动物出现实验性变应性脑脊髓膜炎(EAE)。因此认为在中枢神经系统(CNS)存在自身抗原性。作者认为CNS存在自身抗原性,由于血脑屏障(BBB)和脑脊液(CSF)使CNS处于隔离状态。本实验试图通过脑挫伤后,抗原物质流出CNS,扩散到CSF和末梢的情况 Subcutaneous immunization with CNS tissue easily leads to experimental allergic encephalomyelitis (EAE) in most mammals. It is therefore believed that there is autoantigen in the central nervous system (CNS). Authors believe that CNS is self-antigenic, with CNS isolated by the blood-brain barrier (BBB) ​​and cerebrospinal fluid (CSF). In this experiment, we tried to find out that after the contusion of the brain, the antigen substances flow out of the CNS and spread to the CSF and the distal end