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目的观察布地奈德混悬液加沐舒坦(BSM)氧气驱动雾化吸入治疗对鼻咽癌放疗所致耳鼻并发症的影响。方法 54例鼻咽癌分为两组,每组27例。干预组在放疗期间以BSM氧气驱动雾化吸入治疗;对照组在放疗期间无上述治疗。待放疗结束时比较两组语言频区气导听阈、分泌性中耳炎发生率、副鼻窦炎发生率、鼻腔粘连和后鼻孔狭窄发生率。结果干预组语言频区气导听阈和分泌性中耳炎、副鼻窦炎、鼻腔粘连和后鼻孔狭窄发生率均低于对照组(P<0.05)。结论鼻咽癌放疗期间给予BSM氧气驱动雾化吸入治疗可降低放疗所致耳鼻并发症。
Objective To observe the effect of inhalation of budesonide suspension combined with ambroxol (BSM) oxygen inhalation on nasal and nasal complications caused by radiotherapy of nasopharyngeal carcinoma. Methods 54 cases of nasopharyngeal carcinoma were divided into two groups, 27 cases in each group. The intervention group was treated with BSM oxygen-driven nebulization during radiotherapy and the control group without the above treatment during radiotherapy. At the end of radiotherapy, the incidences of air conduction hearing threshold, secretory otitis media, incidence of paranasal sinusitis, nasal adhesions and posterior nostril stenosis were compared between the two groups. Results The incidence of air conduction hearing threshold, secretory otitis media, sinusitis, nasal adhesions and posterior nostril stenosis were lower in intervention group than those in control group (P <0.05). Conclusion Nasopharyngeal carcinoma given BSM oxygen inhalation during inhalation therapy can reduce ototoxicity caused by otolaryngology complications.