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目的:探讨脊痹汤配合膀胱经背部注射玻璃酸钠治疗活动期强直性脊柱炎的疗效及机制。方法:将70例患者随机分为3组,治疗组(脊痹汤配合膀胱经背部注射玻璃酸钠)32例,对照一组(单纯脊痹汤治疗)18例,对照二组(单纯膀胱经背部注射玻璃酸钠治疗)20例。临床观察3月后,进行疗效统计分析。结果:治疗组总有效率100%,控显率62.50%;对照一组总有效率77.78%,控显率22.22%;对照二组总有效率85.00%,控显率50.00%,治疗组与对照一组比较疗效有显著性差异(P<0.05),与对照二组比较疗效无显著性差异(P>0.05)。结论:脊痹汤配合膀胱经背部注射玻璃酸钠治疗活动期强直性脊柱炎对于改善临床症状、体征,改善整体功能,缩短枕墙距、指地距,降低ESR、CRPI、gA水平等方面均有显著疗效。
Objective: To investigate the therapeutic effect and mechanism of Jiweizang Decoction combined with intravesical instillation of sodium hyaluronate on active ankylosing spondylitis. Methods: Seventy patients were randomly divided into three groups. The treatment group (32 cases in which the treatment group was treated with Jiweizhitang with bladder injection of sodium hyaluronate by the back), the control group (18 cases treated with Jiubi Decoction alone), the control group 2 Back injection of sodium hyaluronate treatment) 20 cases. Clinical observation after 3 months, the efficacy of statistical analysis. Results: The total effective rate was 100% and the control rate was 62.50% in the treatment group. The total effective rate was 77.78% in the control group and 22.22% in the control group. The total effective rate was 85.00% in the control group and 50.00% in the control group. There was significant difference between the two groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusion: Spleenbi Decoction combined with sodium hyaluronate injection in the treatment of ankylosing spondylitis can improve the clinical symptoms and signs, improve the overall function, shorten the distance between the pillow wall and the ground, reduce the ESR, CRPI and gA levels A significant effect.