The target of this paper is the performance-based diagnostics of a gas turbine for the automated early detection of components malfunctions. The paper proposes a new combination of multiple methodologies for the performance-based diagnostics of single and multiple failures on a two-spool engine. The aim of this technique is to combine the strength of each methodology and provide a high success rate for single and multiple failures with the presence of measurement malfunctions. A combination of KF (Kalman Filter), ANN (Artificial Neural Network) and FL (Fuzzy Logic) is used in this research in order to improve the success rate, to increase the flexibility and the number of failures detected and to combine the strength of multiple methods to have a more robust solution. The Kalman filter has in his strength the measurement noise treatment, the artificial neural network the simulation and prediction of reference and deteriorated performance profile and the fuzzy logic the categorization flexibility, which is used to quantify and classify the failures. In the area of GT (Gas Turbine) diagnostics, the multiple failures in combination with measurement issues and the utilization of multiple methods for a 2-spool industrial gas turbine engine has not been investigated extensively.This paper reports the key contribution of each component of the methodology and brief the results in the quantification and classification success rate. The methodology is tested for constant deteri-oration and increasing noise and for random deterioration. For the random deterioration and nom-inal noise of 0.4％, in particular, the quantification success rate is above 92.0％, while the classification success rate is above 95.1％. Moreover, the speed of the data processing (1.7 s/sample) proves the suitability of this methodology for online diagnostics.