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目的:探讨乙型肝炎患者血清腺苷酸脱氨酶(ADA)与肝纤维化血清标志物透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及Ⅲ型前胶原(PCⅢ)检测的意义。方法:选择2011年8月至2012年12月海南省人民医院收治的30例乙型肝炎住院患者作为观察组,同期38例健康体检者为正常对照组,分别检测两组血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平。结果:观察组患者血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平明显高于正常对照组,两组比较,差异有统计学意义(P<0.01)。结论:测定乙型肝炎患者血清ADA的活性与HA、LN、C-Ⅳ、PCⅢ水平的变化,既能了解乙型肝炎患者肝脏损伤程度,又能反映肝纤维化趋势,对乙型肝炎患者肝纤维化早期进行诊断、治疗,减少肝硬化的发生及预后判断有着重要的临床意义。
Objective: To investigate the relationship between serum adenosine deaminase (ADA) and hepatic fibrosis serum markers of hyaluronic acid (HA), laminin (LN), collagen Ⅳ (C-Ⅳ) Significance of detection of collagen (PC Ⅲ). Methods: Thirty patients with hepatitis B admitted to Hainan Provincial People’s Hospital from August 2011 to December 2012 were selected as the observation group. 38 normal healthy subjects were selected as the normal control group. The levels of serum ADA, HA, LN, C-Ⅳ, PCⅢ level. Results: Serum ADA activity, HA, LN, C-Ⅳ and PCⅢ levels in the observation group were significantly higher than those in the normal control group. There was significant difference between the two groups (P <0.01). Conclusion: The determination of serum ADA activity and the changes of HA, LN, C-Ⅳ and PCⅢ levels in patients with hepatitis B can not only understand the degree of liver damage but also the trend of liver fibrosis in patients with hepatitis B, Early diagnosis and treatment of fibrosis, reduce the occurrence of cirrhosis and prognosis has important clinical significance.