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目的 :探讨泌尿系肿瘤患者红细胞免疫功能状况及其在围手术期的变化和意义。方法 :应用郭峰法检测 6 0例泌尿系肿瘤患者和 30例正常者的各项红细胞免疫功能指标。结果 :泌尿系肿瘤患者红细胞 C3b受体花环率 (RCR)、肿瘤红细胞花环率 (TRR)和红细胞 C3b受体花环促进率 (RFER)显著低于正常者 (P <0 .0 1) ,T2 期膀胱肿瘤患者 RCR、TRR和 RFER显著低于 T1 期膀胱肿瘤患者 (P <0 .0 1) ;手术切除肿瘤后 ,RCR、TRR和RFER较术前显著升高 (P <0 .0 1)。结论 :泌尿系肿瘤患者红细胞免疫功能低下 ,免疫调节紊乱 ,手术切除肿瘤后 ,红细胞免疫功能显著改善。对红细胞免疫功能检测可作为肿瘤患者病情、预后及疗效判定的免疫学指标。
Objective: To investigate the status and significance of erythrocyte immune function in perioperative period in patients with urological tumors. Methods: The Guo-fang method was used to detect the indexes of erythrocyte immune function of 60 patients with urinary tract tumors and 30 normal controls. Results: The RBC, TRR and RFER of erythrocyte C3b receptor in patients with urinary tumors were significantly lower than those in normal controls (P <0.01). The level of erythrocyte C3b receptor rosette (RCR), erythrocyte erythrocyte rosette rate The RCR, TRR and RFER of bladder cancer patients were significantly lower than those of T1 bladder cancer patients (P <0.01). The RCR, TRR and RFER were significantly higher than those before surgery (P <0.01) after tumor resection. CONCLUSION: Erythrocyte immune function is low and immune regulation disorder is found in patients with urological tumors. The immune function of erythrocytes is significantly improved after tumor resection. The detection of erythrocyte immune function can be used as an immunological indicator of the condition, prognosis and curative effect of cancer patients.