研究血清结合珠蛋白遗传多态性和疾病的相互关系,可为探讨某些疾病的发生机理提供科学根据。本文测定了哈尔滨地区833例正常人的Hp(baptoglobin)表型,与已明确诊断的8种疾病共计909例患者和795例门诊患者的Hp表型进行对比。结果表明,结合球蛋白的Hp~1基因频率在肝硬化、肺气肿、肝癌和胃癌患者中显著增高,和正常人存在统计学差异。 Studying the relationship between serum Haptoglobin genetic polymorphisms and diseases can provide a scientific basis for exploring the pathogenesis of certain diseases. In this paper, we measured the phenotype of Hp (baptoglobin) in 833 normal subjects in Harbin and compared the Hp phenotypes of 909 patients and 795 outpatients with 8 diagnosed diseases. The results showed that the frequency of Hp ~ 1 binding to globulin was significantly increased in patients with cirrhosis, emphysema, liver cancer and gastric cancer, and there was a significant difference compared with normal people.