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目的明确柳州市20岁以上人群高尿酸血症(HUA)的患病率及其影响因素。方法对51 206名体检居民进行横断面调查,运用Logistic多元回归模型对与高尿酸血症相关的人口学特征及临床指标进行分析。结果该人群中男性高尿酸血症患者10 722例,占39.5%;女性患者3 459例,占14.4%。Logistic多元回归模型统计显示,男性、高胆固醇血症、血高密度脂蛋白胆固醇降低、血肌酐升高、血尿素氮升高、血胱抑素C升高、血谷丙转氨酶升高、血γ-谷氨酰转移酶升高与高尿酸血症的患病率升高相关,而高密度脂蛋白胆固醇降低与高尿酸血症的患病率升高相关。结论柳州市人群高尿酸血症的发病率较高;男性、高胆固醇血症、血肌酐升高、血尿素氮升高、血胱抑素C升高、血谷丙转氨酶升高、血γ-谷氨酰转移酶升高可能是高尿酸血症的危险因素,高密度脂蛋白胆固醇升高可能是其保护因素。
Objective To determine the prevalence of hyperuricemia (HUA) and its influencing factors in people over the age of 20 in Liuzhou city. Methods A cross-sectional survey of 51 206 residents was conducted and the demographic characteristics and clinical indicators related to hyperuricemia were analyzed by Logistic multiple regression model. Results A total of 10 722 male patients with hyperuricemia were found in this population, accounting for 39.5%. There were 3 459 female patients, accounting for 14.4%. Logistic multivariate regression model statistics showed that men, hypercholesterolemia, decreased serum high-density lipoprotein cholesterol, elevated serum creatinine, elevated blood urea nitrogen, elevated serum cystatin C, elevated blood alanine aminotransferase, and blood γ - Elevated glutamyl transferase correlates with an increased prevalence of hyperuricemia, whereas a decrease in high-density lipoprotein cholesterol is associated with an increased prevalence of hyperuricemia. Conclusions The incidence of hyperuricemia is high in the population in Liuzhou City. In men, hypercholesterolemia, elevated serum creatinine, elevated blood urea nitrogen, elevated serum cystatin C, elevated blood alanine aminotransferase, Elevated glutamyl transferase may be a risk factor for hyperuricemia, and elevated HDL cholesterol may be its protective factor.