Background:Primary angle-closure glaucoma (PACG) is a common eye disease and a common cause of blindness.Inappropriate medical decisions severely affect the prognosis.This study investigated decision-making under risk in PACG patients.Methods:Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study.Decision-making under risk was evaluated with the game of dice task (GDT).The results of Eysenck Personality Questionnaire (EPQ) and GDT between PACG patients and healthy controls were compared.Results:Risky decisions in PACG patients were more than those in healthy controls as measured by mean score of GDT (12.47 ± 5.72 vs.4.33 ± 3.30,P ＜ 0.001).Higher neuroticism score in EPQ was found in PACG patients compared to healthy controls (14.97 ± 3.93 vs.9.90 ± 4.49,P ＜ 0.001).Neuroticism scores in EPQ were associated with decision-making performance (r =0.417,P =0.00 l).Conclusions:Neuroticism positively correlated with risky decisions.Decision-making might be influenced by neuroticism.Future studies will show whether therapy compliance will be improved by emotional management and psychological intervention in PACG patients.