In this paper, the holomorphic sectional curvature under invariant metric on a Cartan-Hartogs domain of the second type YII(N,p,K) is presented and an invariant K?]lher metric which is complete and not less than the Bergman metric is constructed, such that its holomorphic sectional curvature is bounded above by a negative constant. Hence a comparison theorem for the Bergman and Kobayashi metrics on YII(N,p,K) is obtained.