对 41例慢性病毒性肝炎患者在IFN治疗前、中、后采用ELISA法检测抗IFN、HBV -M ,用PCR法检测HBVDNA、HCVRNA ,结果 ,乙型肝炎抗IFN治后转阳性及治前后均阴性组 ,HBeAg阴转及HBVDNA的阴转均略优于治疗前抗IFN阳性组 ,但无显著差异 (P >0 .0 5 ) ;丙型肝炎 ,ALT复常、HCVRNA的阴转 ,治前后均阴性组好于治后转为阳性组又好于治前阳性组 (P <0 .0 5 )。 78.3%的患者抗IFN出现高峰在 2～ 3个月。结果表明治疗前已存在有抗IFN者 ,对α-干扰素疗效的反应比治疗后诱生的干扰素抗体的病人差。 Anti-IFN and HBV-M were detected by ELISA before and after IFN treatment in 41 patients with chronic viral hepatitis, HBVDNA and HCVRNA were detected by PCR, and the results were positive and negative after treatment The negative conversion rate of HBeAg negative and HBVDNA was slightly better than that before treatment, but there was no significant difference (P> 0.05); Hepatitis C, ALT normalization, HCV RNA negative conversion, The negative group was better than the control group into positive group and better than the pre-treatment group (P <0.05). In 78.3% of the patients, the peak of anti-IFN appeared in 2 ~ 3 months. The results showed that there was an anti-IFN before treatment, the response to the effect of interferon-alpha was worse than that of the interferon antibody induced after treatment.