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目的分析复方肾炎片佐治糖尿病肾病的临床疗效及安全性。方法将入选的112例患者随机分为观察组和对照组各56例,两组患者均给予综合治疗,包括合理休息,戒烟限酒,低盐、低脂、低胆固醇、低蛋白饮食,控制血糖、血压及血脂,纠正水电解质及酸碱失衡,口服雷公藤多甙片及贝那普利。观察组在此基础上加服复方肾炎片。两组患者均连续治疗3个月。观察两组患者治疗前后临床症状、体征的变化及不良反应,动态监测尿常规及24 h尿蛋白定量,检测血清肌酐(Scr)、尿素氮(BUN)、内生肌酐(Ccr)、肝功能及心电图。结果观察组临床症状及体征比对照组明显改善,其治疗总有效率达91.3%,明显高于对照组的76.8%(P﹤0.01);两组患者治疗后24 h尿蛋白定量、Scr、BUN、Ccr等指标均较治疗前明显改善(P﹤0.01),但观察组改善程度明显优于对照组(P均﹤0.01)。两组患者均未出现皮疹、肝功能损害及心电图异常等不良反应。结论复方肾炎片佐治糖尿病肾病疗效确切,安全性好,且价格较低廉,适合基层医院应用。
Objective To analyze the clinical efficacy and safety of compound nephritis tablets in the treatment of diabetic nephropathy. Methods One hundred and twelve patients were randomly divided into observation group (n = 56) and control group (n = 56). The patients in both groups were given comprehensive treatment including reasonable rest, alcohol restriction, low salt, low fat, low cholesterol and low protein diet, , Blood pressure and blood lipids, correct water and electrolyte and acid-base imbalance, oral tripterygium glycosides tablet and benazepril. Observation group on the basis of this service plus compound nephritis tablets. Two groups of patients were treated for 3 months. The changes of clinical symptoms and signs and adverse reactions before and after treatment in both groups were observed. The urinary routine and 24 h urinary protein were dynamically monitored. Serum creatinine (Scr), blood urea nitrogen (BUN), endogenous creatinine (Ccr), liver function Electrocardiogram. Results The clinical symptoms and signs of the observation group were significantly improved compared with the control group. The total effective rate was 91.3%, significantly higher than that of the control group (76.8%, P <0.01). Urine protein, Scr, BUN , Ccr and other indicators were significantly improved than before treatment (P <0.01), but the observation group improved significantly better than the control group (P all <0.01). Two groups of patients did not appear rash, liver dysfunction and ECG abnormalities and other adverse reactions. Conclusion Compound nephritis tablets for the treatment of diabetic nephropathy curative effect is accurate, safe, and the price is relatively low, suitable for primary hospital applications.