论文部分内容阅读
目的探讨老年急性冠脉综合征(ACS)患者血浆可溶性细胞间黏附分子-1(sICAM-1)和超敏C反应蛋白(hsCRP)的表达及阿托伐他汀对其影响。方法用ELISA法测定90例ACS患者和40例稳定性心绞痛(SAP)患者血浆sICAM-1和hsCRP水平。结果 ACS组sICAM-1和hsCRP水平均高于SAP组(P<0.05,P<0.01);阿托伐他汀治疗后,B、D组sICAM-1和hsCRP水平较治疗前降低。结论血浆sICAM-1和hsCRP水平与不同类型冠心病斑块稳定性和内皮炎症有关,阿托伐他汀具有稳定动脉粥样硬化斑块,抑制内皮炎症的作用。
Objective To investigate the expression of plasma soluble intercellular adhesion molecule-1 (sICAM-1) and hsCRP in elderly patients with acute coronary syndrome (ACS) and the effect of atorvastatin on it. Methods Serum levels of sICAM-1 and hsCRP in 90 patients with ACS and 40 patients with stable angina pectoris (SAP) were measured by ELISA. Results The levels of sICAM-1 and hsCRP in ACS group were significantly higher than those in SAP group (P <0.05, P <0.01). After atorvastatin treatment, the levels of sICAM-1 and hsCRP in group B and D were lower than those before treatment. Conclusions Plasma levels of sICAM-1 and hsCRP are correlated with plaque stability and endothelial inflammation in different types of coronary heart disease. Atorvastatin has the effect of stabilizing atherosclerotic plaque and inhibiting endothelium inflammation.