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在老化与神经变性疾病中引起铁沉积与线粒体破坏的机制尚不明确。血红素加氧酶-1(HO-1)属于应激蛋白超家族的一员,将血红素降解为铁离子、一氧化碳与胆绿素,以此在帕金森病以及阿尔茨海默病等神经变性疾病中发挥重要的作用。
The mechanisms that cause iron deposition and mitochondrial destruction in aging and neurodegenerative diseases are unclear. Heme oxygenase-1 (HO-1), a member of the stress protein superfamily, degrades heme to iron ions, carbon monoxide, and biliverdin, thereby reducing the number of neurons in Parkinson’s disease and Alzheimer’s disease Degenerative diseases play an important role.