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目的观察地塞米松对重症急性胰腺炎多脏器(胰腺、肺、肾、肝)损伤大鼠的保护作用。方法采用改良Aho法制备SAP大鼠模型,设模型组、地塞米松治疗组、假手术组。各组分别于术后3h,6h,12h观察存活率,多脏器大体及光镜下病理变化。结果模型组和地塞米松治疗组在各时点存活率无明显差异(P>0.05)。多脏器病理评分不同时间点模型组和治疗组均明显大于假手术组(P<0.001,P<0.05),治疗组不同程度小于模型组(P<0.05,P<0.01)。结论地塞米松能够减轻SAP大鼠胰腺、肺、肾及肝脏的损伤,对SAP大鼠多脏器损伤具有保护作用。
Objective To observe the protective effect of dexamethasone on multiple organ injury (pancreas, lung, kidney and liver) in rats with severe acute pancreatitis. Methods SAP model was established by modified Aho method. The model group, dexamethasone group and sham group were established. The survival rates of each group were observed at 3h, 6h, 12h after operation, and the pathological changes were observed under multiple organs and light microscope. Results There was no significant difference in survival between model group and dexamethasone group at each time point (P> 0.05). The pathological score of multiple organ at different time points in model group and treatment group were significantly greater than those in sham operation group (P <0.001, P <0.05). The treatment group was less than model group (P <0.05, P <0.01). Conclusion Dexamethasone can reduce the damage of pancreas, lung, kidney and liver of SAP rats and protect the multiple organ injury of SAP rats.