越来越多的证据表明线粒体功能障碍在许多神经变性疾病的发生中有重要作用。线粒体不仅是能量的“加工厂” ,也是自由基产生的场所 ,线粒体功能障碍引起能量产生不足和氧化损伤 ,细胞发生凋亡 ,最终导致神经元变性。线粒体不仅对细胞凋亡起着启动和调控作用 ,而且是细胞凋亡的 There is growing evidence that mitochondrial dysfunction plays an important role in the development of many neurodegenerative diseases. Mitochondria are not only “factories” of energy, but also sites where free radicals are generated. Mitochondrial dysfunction causes energy deficits and oxidative damage, leading to apoptosis of cells and eventually neuronal degeneration. Mitochondria not only play a role in the initiation and regulation of apoptosis, but also apoptosis