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地方性克汀病为(以下简称地克病)多系统损害的一组临床症侯群,这组临床症侯群系由于严重的环境碘缺乏造成,并以中枢神经系统损害为主要特征。至此,许多学者已经对严重碘缺乏大鼠中枢神经系统病变做过大量的形态学研究,表明,严重碘缺乏可致甲状腺功能低下,后者在新生期可致中枢神经系统内神经元和神经胶质细胞的移行、分化和成熟受到影响,也可导致神经元树突减少,轴突数目和突触减少,从而导致中枢神经系统信息处理结构的复杂程度降低,但几乎所有这些研究都集中在对大脑皮质和小脑皮质的研究。这些研究对于阐明甲状腺激素对中枢神经系统分化、发育所起的作用,以及克汀病时神经系统的损害具有
The endemic cretinism is a group of clinical syndromes caused by multiple system damages (hereinafter referred to as gram gram disease). This group of clinical syndromes is mainly caused by the iodine deficiency in the environment, which is characterized by central nervous system damage. So far, many scholars have done a lot of morphological studies of severe iodine deficiency rat central nervous system lesions, indicating that severe iodine deficiency can cause hypothyroidism, which in the neonatal period can cause central nervous system neurons and glue Affecting the migration, differentiation and maturation of stromal cells can also lead to fewer dendrites in neurons, fewer axons, and fewer synapses, leading to a reduction in the complexity of CNS information processing structures, but almost all of these studies focus on Study of the cerebral cortex and cerebellar cortex. These studies to clarify the thyroid hormone on the central nervous system differentiation and development, as well as cretinism nervous system damage with