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正常生理情况下,大脑小胶质细胞与神经元之间存在广泛的细胞通讯,但少突胶质细胞与小胶质细胞之间的细胞通讯却知之甚少。当脱髓鞘疾病(如多发性硬化)发生时,少突胶质细胞是主要受损细胞。其实少突胶质细胞也具有较强免疫功能,它可通过表达多种受体调节中枢神经免疫反应、启动一系列保护或再生机制应对大脑应激并阻止进一步神经退行性变的发生。加强对小胶质细胞和少突胶质细胞之间细胞通讯的认识将有助于发现脑中免疫调节的新途径,有利于神经炎症和神经退行性疾病的治疗,本文将对这两种细胞之间的细胞通讯进行综述。
Under normal physiological conditions, there is extensive cellular communication between microglia and neurons in the brain, but cell communication between oligodendrocytes and microglia is poorly understood. Oligodendrocytes are the major damaged cells when demyelinating diseases such as multiple sclerosis occur. In fact, oligodendrocytes also have a strong immune function, which can regulate the central nervous system through a variety of receptors for immune response, start a series of protective or regenerative mechanisms to deal with brain stress and prevent further neurodegeneration. Enhancing understanding of the cellular communication between microglia and oligodendrocytes will help to find new ways of immunomodulating the brain that are conducive to the treatment of neuroinflammation and neurodegenerative diseases. Cell communication between the review.