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本文对肝素的作用机理及应用提出了一些新的概念。四十多年以来,肝素已作为诊断和治疗心血管疾病的一种必不可少的药物。商品肝素是由牛肺和猪肠粘膜制备的。1976年,美国几乎有1千万病人用了9千亿单位(6吨)的肝素。1974～1976年,每年消耗增加约3千亿单位。一、肝素的化学性质肝素是具有正旋光性的酸性糖类,能与金属形成盐,含糖醛酸、葡糖胺和硫酸酯成分。从肝素的硫含量、与高碘酸和亚硝酸反应迟缓、还原能力很低、不能透析以及平均分子量范围(7600～19700)等方面来看,它是多分散性的物质,由硫酸葡糖胺和己糖醛酸分
In this paper, the mechanism of heparin and its application put forward some new concepts. For more than 40 years, heparin has been used as an essential drug in the diagnosis and treatment of cardiovascular diseases. Commodity heparin is prepared from bovine lung and porcine intestinal mucosa. In 1976, almost 10 million patients in the United States spent 90 billion units (6 tons) of heparin. From 1974 to 1976, annual consumption increased by about 300 billion units. First, the chemical properties of heparin Heparin is a positive optical acidity of sugar, with the metal salt, containing uronic acid, glucosamine and sulfate components. It is a polydisperse substance from the aspects of the sulfur content of heparin, the slow reaction with periodic acid and nitrous acid, the low reducing ability, the inability to dialyze and the average molecular weight range (7600 to 19700), and is composed of glucosamine sulfate And hexuronic acid points