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本文报告用卡托普利治疗高血压和心衰284例,发生咳嗽反应14例,分析如下。临床资料发生咳嗽反应的14例中,男5例,女9例;高血压病12例,冠心病和风心病各1例;心功能Ⅲ级1例,Ⅱ级3例,Ⅰ级10例;既往有吸烟史2例,慢支史有4例,药物(青霉素)过敏史2例。口服卡托普利12.5～100mg/日,逐步调整至12.5～37.5mg/日、50～100mg/日。副反应判断依据:服药期间出现不能用其他原因解释的和治疗无效的咳嗽,经X 线胸部摄片和血常规检查均无异常发现,停药后咳嗽消失,重复用药,咳嗽又重复出现。咳嗽特点及有关因素:(1)咳嗽为刺激性干咳,咽部痒感,卧位时加重,持续时间愈长
This paper reports the use of captopril treatment of hypertension and heart failure in 284 cases, 14 cases of cough reaction, analysis is as follows. Clinical data of cough in 14 cases, 5 males and 9 females; hypertension in 12 cases, 1 case of coronary heart disease and rheumatic heart disease; heart function in 1 case, Ⅱ in 3 cases, Ⅰ in 10 cases; past There are 2 cases of smoking history, history of chronic bronchitis in 4 cases, drug (penicillin) allergy in 2 cases. Oral captopril 12.5 ~ 100mg / day, and gradually adjusted to 12.5 ~ 37.5mg / day, 50 ~ 100mg / day. Side reactions to determine the basis: During the medication can not be explained by other reasons and treatment of cough, chest X-ray and blood tests were no abnormal findings, cough disappeared after drug withdrawal, repeated medication, cough recurring. Cough characteristics and related factors: (1) cough irritating dry cough, itchy pharynx, lying heavier, the longer the duration