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目的探讨间质性膀胱炎合并盆底疼痛进行骶神经电刺激神经调节治疗的疗效。方法2004年11月至2005年12月,采用美国国立糖尿病、消化病和肾病研究所(NIDDK)制定的标准诊断间质性膀胱炎合并盆底疼痛者4例,并接受永久性神经调节器植入。结果4例经永久性神经调节器植入后,分别随访3-8个月,排尿日记24 h平均尿量由治疗前90-110(96．3±9．3)ml升至治疗后的192～212(201．0±9．2)ml,P<0．05),24 h排尿次数由治疗前的15-25(20．3±4．1)次降至7～12(9．8±2．2)次(P<0．05),夜尿次数由治疗前的8～11(9.8±1.5)次降至治疗后3-6 (4．3±1．3)次(P<0．05),排尿疼痛评分由治疗前的7～10(8．8±1．5)分降至治疗后的1～4(1．8±1．5)分(P<0．01);O’Leary-Sant间质性膀胱炎指数评分由治疗前的均为满分(36分)降至治疗后的8 -11(9．3±1．5)分(P<0．01)。膀胱疼痛和盆底疼痛症状明显缓解,尿频症状也明显改善。结论骶神经电刺激神经凋节治疗是治疗间质性膀胱炎合并盆底疼痛有效、安全的治疗手段。
Objective To investigate the efficacy of sacral nerve electrical stimulation of neuromodulation in patients with interstitial cystitis complicated with pelvic pain. Methods From November 2004 to December 2005, 4 patients with interstitial cystitis and pelvic pain were diagnosed by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and received permanent neuroregulator Into. Results Four patients were followed up for 3-8 months after permanent neuroregulator implantation. The average urinary output of urination diary increased from 90-110 (96.3 ± 9.3) ml before treatment to 192 after treatment ~201 (201.0 ± 9.2) ml, P <0.05). The frequency of urination in 24 hours decreased from 15.25 (20.3 ± 4.1) to 7-12 (9.8 ± 2.2) times (P <0.05), and the frequency of nocturnal urination decreased from 8-11 (9.8 ± 1.5) before treatment to 3-6 (4.3 ± 1.3) after treatment (P < 0.05). The urination pain score decreased from 7 ~ 10 (8.8 ± 1.5) before treatment to 1 ~ 4 (1.8 ± 1.5) after treatment (P0.01) The score of O’Leary-Sant interstitial cystitis index decreased from full score (36 points) before treatment to 8 -11 (9.3 ± 1.5) points after treatment (P <0.01). Bladder pain and pelvic floor pain symptoms were significantly alleviated, urinary frequency symptoms also significantly improved. Conclusion Sacral nerve electrical stimulation of neurological apoptosis is an effective and safe treatment for interstitial cystitis complicated pelvic pain.