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颅咽管瘤是儿童最常见的鞍区上皮来源性肿瘤,暂分为釉质上皮型和鳞状乳突型两型,起源尚存争议,现有“胚胎上皮理论”和“鳞状上皮化生理论”学说分别解释其肿瘤来源;近年来,该肿瘤体外细胞系、体内动物模型得到改进,在此基础上使得肿瘤发生、发展机制,特别是Wnt通路与肿瘤相关性、肿瘤与微环境间相互联系得到进一步认识。随着对颅咽管瘤基础研究深入,有望进一步规范颅咽管瘤的治疗策略,提高患者术后生存质量,改善预后。
Craniopharyngioma is the most common sellar epithelial tumor in children. It is divided into enamel epithelial type and squamous papilla type. The origin is still controversial. The existing “embryo epithelial theory” and “squamous Epithelial metaplasia theory ”, respectively, to explain their sources of cancer; in recent years, the tumor cell lines in vitro and in vivo animal model has been improved, based on this makes tumorigenesis, developmental mechanisms, especially Wnt pathway and tumor-related, tumor and Micro environment interrelated get further understanding. With the basic research on craniopharyngioma in-depth, is expected to further standardize the treatment of craniopharyngioma strategy to improve postoperative quality of life and improve prognosis.