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目的探讨PRKCB1基因rs3760106变异与2型糖尿病终末期肾病(ESRD)的关系。方法选取上海地区汉族174例2型糖尿病终末期肾病(DN-ESRD组)和228例糖尿病无肾病患者(DN-0组)为研究对象。采用Taqman探针法检测rs3760106(C/T)基因型,对两组基因型、等位基因频率分布及临床变量进行比较分析。结果 DN-0组与DN-ESRD组rs3760106基因型和等位基因频率分布的差异均有统计学意义(P<0.05);与CC基因型相比,CT+TT基因型携带者发生DN-ESRD的风险显著增高,OR(95%CI)为2.14(1.18~3.87)(P<0.05)。校正性别、糖尿病发病年龄和体质量指数(BMI)后,CT+TT基因型携带者发生DN-ESRD的风险依然存在,OR(95%CI)为2.47(1.03~5.94)(P<0.05)。在DN-0组或DN-ESRD组,与CC基因型相比,CT+TT基因型携带者的空腹血糖(FPG)水平显著增加(P<0.05)或呈增高趋势(P>0.05)。结论上海地区汉族人2型糖尿病PRKCB1基因rs3760106T等位基因携带者的ESRD发病风险显著增高。
Objective To investigate the relationship between rs3760106 mutation of PRKCB1 gene and type 2 diabetic end-stage renal disease (ESRD). Methods A total of 174 Chinese Han patients with type 2 diabetic end-stage renal disease (DN-ESRD group) and 228 diabetic nephropathy patients (DN-0 group) were selected as the study subjects. The genotypes of rs3760106 (C / T) were detected by Taqman probe method, and the genotype, allele frequency distribution and clinical variables of the two groups were compared and analyzed. Results The frequencies of rs3760106 genotypes and alleles in DN-0 group and DN-ESRD group were significantly different (P <0.05). Compared with CC genotype, DN-ESRD The odds ratio (OR 95% CI) was 2.14 (1.18-3.87) (P <0.05). After adjusting for gender, age at onset of diabetes, and body mass index (BMI), the risk of DN-ESRD was still present in CT + TT carriers with an OR (95% CI) of 2.47 (1.03-5.94) (P <0.05). Compared with CC genotype, fasting plasma glucose (FPG) levels of CT + TT genotypes increased significantly (P <0.05) or increased in DN-0 group or DN-ESRD group (P> 0.05). Conclusion The incidence of ESRD in PR37C allele rs3760106T allele of type 2 diabetes in Han Chinese patients in Shanghai area was significantly higher.