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目的分析盐酸纳美芬给药时机对腹腔镜下异位妊娠手术麻醉复苏的不同效果。方法随机选择该院2014年1月-2015年12月就诊的60例患有异位妊娠并符合腹腔镜下手术指征的患者,采用随机抽签方式将患者分为A组(麻醉停药前组)、B组(麻醉停药时组)、C组(麻醉停药后组),每组各20例。分别在麻醉停药前5 min、停药时、停药后5 min给予0.25μg/kg盐酸纳美芬。观察拔气管导管时间等指标以及血压、心率等在用药前后的变化和不良反应情况。结果拔气管导管时间等指标A组与C组、B组与C组比较差异具有统计学意义(P<0.05),而A组与B组比较差异无统计学意义(P>0.05);3组患者在麻醉维持时间上差异无统计学意义(P>0.05);RASS和VAS两种评分结果 A组与B组、A组与C组比较差异具有统计学意义(P<0.05)。麻醉不同时间心率、血压等变化,组间比较差异无统计学意义(P>0.05);不良反应情况比较差异无统计学意义(P>0.05)。给药前后心率、血压等较麻醉前明显上升,差异具有统计学意义(P<0.05)。结论 3组患者给予盐酸纳美芬可以加快患者呼吸功能恢复,而A组和B组给予盐酸纳美芬可以帮助患者减轻术后躁动。因此,麻醉停药时给予盐酸纳美芬,可以加快患者呼吸恢复和减轻躁动。
Objective To analyze the different effects of nalmefene hydrochloride timing on anesthesia recovery during laparoscopic ectopic pregnancy. Methods A total of 60 patients with ectopic pregnancy who met the indications of laparoscopic surgery from January 2014 to December 2015 in our hospital were randomly selected and randomly divided into group A ), Group B (anesthesia withdrawal group), group C (anesthesia withdrawal group), 20 cases in each group. Respectively in anesthesia withdrawal 5 min, withdrawal, 5 min after stopping to give 0.25 μg / kg nalmefene hydrochloride. Observation of tracheal catheter time and other indicators as well as blood pressure, heart rate and other changes in the medication before and after the adverse reactions. Results The time of tracheal intubation was significantly higher in group A than in group C, group B and group C (P <0.05), but there was no significant difference between group A and group B (P> 0.05); Group 3 There was no significant difference in the duration of anesthesia between the two groups (P> 0.05). There was significant difference between group A and group B, group A and group C (P <0.05). There was no significant difference between the two groups in heart rate and blood pressure during anesthesia (P> 0.05). There was no significant difference in adverse reactions between two groups (P> 0.05). Heart rate and blood pressure before and after administration were significantly higher than before anesthesia, the difference was statistically significant (P <0.05). Conclusion Nalmefene hydrochloride can accelerate the recovery of respiratory function in three groups, while nalmefene hydrochloride in groups A and B can help patients to relieve postoperative agitation. Therefore, nalmefene hydrochloride is given when anesthesia is discontinued, which can speed up patient’s respiratory recovery and relieve agitation.