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本实验证明,人工合成的抗心律失常肽(AAP)能明显对抗乌头硷诱发的小白鼠室性心动过速,异搏定无此作用且加重了心律失常。AAP可显著减少CaCl_2—Ach诱发的小白鼠房颤(或室颤)及心室停跳的发生,显著缩短恢复窦性心律的时间。大剂量异搏定也有同样作用,但窦性心动过缓的发生率较高,且低剂量异搏定(0.625mg/kg)即可显著延长小白鼠心电图P-P及P-R间期,而AAP无此作用。AAP具有明显的抗心律失常作用且优于异博定。
This experiment shows that synthetic anti-arrhythmic peptide (AAP) can significantly antagonize the aconitine-induced ventricular tachycardia in mice, verapamil does not have this effect and aggravate the arrhythmia. AAP can significantly reduce the occurrence of atrial fibrillation (or ventricular fibrillation) and ventricular arrest in mice induced by CaCl 2 -Ach, significantly shortening the recovery of sinus rhythm. High-dose verapamil also has the same effect, but the incidence of sinus bradycardia is higher, and low-dose verapamil (0.625mg / kg) can significantly prolong the electrocardiogram PP and PR interval mice, while AAP without effect. AAP has a clear antiarrhythmic effect and is superior to ibovine.