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目的:探讨广东地区汉族人鼻咽癌和DPB1-3’调控区的相关性,寻找易感基因类型。方法:对104例广东藉的汉族NPC患者和105例广东藉对照者进行HLA-DPB1基因调控区分型及比较。结果:鼻咽癌组DPB1位点3’调控区BB基因型、B单倍型等位基因分布频率、明显高于对照组。结论:DPB1位点3’调控区BB基因型、B单倍型等位基因可能与广东地区汉族人群鼻咽癌的发生有关。
Objective: To investigate the correlation between NPC and DPB1-3 ’regulatory region of Han nationality in Guangdong and find out the types of susceptible genes. Methods: HLA-DPB1 genes were genotyped and compared in 104 cases of NPC patients from Guangdong and 105 cases of control subjects from Guangdong. Results: The distribution frequencies of BB genotype and B haplotype allele in 3 ’regulatory region of DPB1 in nasopharyngeal carcinoma group were significantly higher than those in control group. Conclusion: BB genotype and B haplotype allele in 3 ’regulatory region of DPB1 may be related to the occurrence of NPC in Guangdong Han population.