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目的:探讨环形电切术(LEEP)治疗宫颈上皮内瘤变(CIN)的效果。方法:对2009年1月～2012年1月承德市妇幼保健院经病理检查明确诊断为宫颈上皮内瘤变的415例患者进行LEEP术治疗,分别于术后3、6、9、12个月进行液基细胞学检查(TCT)、DNA细胞学定量分析及阴道镜下病灶活检,并对患者进行1～2年的随访。结果:415例患者中,宫颈光滑和轻度柱状上皮异位84例,占20.24%;中重度宫颈柱状上皮异位331例,占79.76%;415例术后均无CIN残留及复发,术后6～12月TCT异常6例,DNA细胞学定量分析倍体异常13例,术后12月治愈率94.88%,术后345例患者性感觉无变化,44例性生活无不适感,15例性生活疼痛,术后70例有生育要求患者随访24～36月,妊娠65例,异位妊娠2例,流产7例,早产9例,足月分娩41例。结论 :LEEP术治疗宫颈CIN安全有效,对性生活及妊娠未见明显影响。
Objective: To investigate the effect of ring electrosurgery (LEEP) in the treatment of cervical intraepithelial neoplasia (CIN). Methods: From January 2009 to January 2012, 415 cases of cervical intraepithelial neoplasia diagnosed by pathological examination in Chengde Maternal and Child Health Hospital were treated with LEEP, and were treated with LEEP at 3, 6, 9 and 12 months Liquid-based cytology (TCT), DNA cytology and colposcopy lesion biopsy were performed and patients were followed up for 1 to 2 years. Results: Of the 415 patients, 84 cases were smooth and mild columnar epithelial ectopic, accounting for 20.24%; 331 cases were moderate or severe cervical columnar ectopic, accounting for 79.76%; 415 cases had no residual and recurrence after operation, Six cases of abnormal TCT from June to December were analyzed by DNA cytology in 13 cases, and the cure rate was 94.88% at December after surgery. There were no changes in sensory perception in 345 cases, no discomfort in 44 cases and 15 cases Life pain, postoperative 70 cases of patients with reproductive requirements were followed up 24 to 36 months, 65 cases of pregnancy, 2 cases of ectopic pregnancy, abortion in 7 cases, premature delivery in 9 cases, 41 cases of full-term delivery. Conclusion: LEEP is safe and effective in treating cervical CIN, but no significant effect on sexual life and pregnancy.