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胃泌素通过胃泌素受体介导,刺激胃酸的分泌,又维持胃黏膜的完整性。胃泌素与脾虚的关系密切,脾虚病理过程中胃泌素水平处于紊乱状态。本研究观察到:脾虚大鼠胃壁细胞胃泌素受体结合位点数下降而受体亲和力升高;与胃黏膜保护机制相关的一氧化氮在胃黏膜中含量下降;经五肽胃泌素腹腔注射刺激后的胃酸分泌反应性显著升高。经益气健脾复方补中益气汤治疗后,以上紊乱状态均获得一定程度的恢复。另证明体外补中益气汤含药血清给药能与胃泌素受体竞争性结合。总之,文章阐明了补中益气汤的健脾机制与调节胃泌素相关。
Gastrin is mediated through gastrin receptors, stimulates the secretion of gastric acid, and maintains the integrity of the gastric mucosa. Gastrin is closely related to spleen deficiency, and gastrin levels are in disorder during pathological process of spleen deficiency. In this study, we observed that the number of gastrin receptor binding sites in gastric parietal cells of spleen deficiency rats decreased and the affinity of receptors increased; the level of nitric oxide associated with the protective mechanism of gastric mucosa decreased in gastric mucosa; The stimulation of gastric acid secretion after injection stimulated significantly. After treatment with Yiqi Jianpi Compound Buzhong Yiqi Decoction, the above disorders were recovered to some extent. In addition, it was proved that in vitro administration of Buzhong Yiqi Decoction containing serum can compete with gastrin receptor for competitive binding. In conclusion, the article clarified that the mechanism of strengthening spleen of Buzhong Yiqi Decoction is related to the regulation of gastrin.