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目的观察复方利多卡因乳膏用于缓解复发性流产患者免疫治疗中的镇痛效果。方法 150例行淋巴细胞主动免疫治疗的习惯性流产患者,随机分为试验组和对照组,各75例。试验组于治疗前在注射部位涂覆复方利多卡因乳膏,对照组采用常规注射法。观察两组患者注射时对疼痛的反应,并于5 min内完成对患者疼痛反应的界定。结果试验组轻度疼痛和中度疼痛的患者多于对照组,重度疼痛患者少于对照组,差异有统计学意义(P<0.05);两组患者治疗后封闭抗体转阳率比较,差异无统计学意义(P>0.05)。结论复方利多卡因乳膏在缓解免疫注射时的疼痛效果明显,可提高免疫治疗的可接受性,且操作简单,不良反应少,值得推广。
Objective To observe the analgesic effect of compound lidocaine cream in relieving immunotherapy of recurrent spontaneous abortion. Methods A total of 150 routine abortion patients undergoing active immunotherapy with lymphocytes were randomly divided into experimental group and control group, with 75 cases in each group. The experimental group was treated with compound lidocaine cream at the injection site before treatment and the control group by conventional injection method. The response of the two groups of patients to pain was observed and the patient’s pain response was defined within 5 minutes. Results There were more patients with mild pain and moderate pain in the experimental group than those in the control group, and those with severe pain were less than those in the control group (P <0.05). There was no significant difference between the two groups in the positive rate of blocking antibody after treatment Statistical significance (P> 0.05). Conclusions The compound lidocaine cream can relieve the pain of immunization obviously and improve the acceptability of immunotherapy. It is easy to operate and has few side effects and should be popularized.