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本文用自行建立的双单抗夹心ＥＬＩＳＡ检测了６６例正常成人及１１例急性肝炎、１７例肝硬化、７１例原发性肝细胞癌、１６例继发性肝癌、１例肝血管瘤患者血清中ｓＴＮＦＲⅠ水平及其中部分病人血清的ｓＴＮ－ＦＲⅡ水平，同时还测定了１０份腹水中ｓＴＮＦＲⅠ浓度，并动态观察了治疗对肝癌患者血清ｓＴＮＦＲⅠ浓度的影响。探讨了ｓＴＮＦＲⅠ与其它实验室参数之间的关系，对于进一步了解肝脏疾病患者的免疫状态，综合评价ｓＴＮＦＲ的临床检测价值具有重要意义。
In this study, double-antibody sandwich ELISA was used to detect 66 cases of normal adults and 11 cases of acute hepatitis, 17 cases of cirrhosis, 71 cases of primary hepatocellular carcinoma, 16 cases of secondary liver cancer, 1 case of liver hemangioma serum STNFR Ⅰ levels in serum and sTN-FRⅡ level in serum of some patients. Meanwhile, the sTNFR Ⅰ levels in 10 ascites were also measured. The effect of treatment on serum sTNFR Ⅰ concentration in patients with liver cancer was also dynamically observed. The relationship between sTNFRI and other laboratory parameters was discussed. It is of great significance to further understand the immune status of patients with liver disease and evaluate the clinical value of sTNFR comprehensively.