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目的探讨中药注射剂静脉滴注所致不良反应的原因及预防措施。方法选取2012—2014年新化县人民医院收治的中药注射剂静脉滴注所致不良反应患者及中国知网、万方、维普等数据库中文献报道的中药注射剂静脉滴注所致不良反应患者共86例。回顾性分析患者一般情况及不良反应发生情况。结果本组患者中药注射剂静脉滴注所致不良反应主要累及皮肤及其附件,所占比例高于其他系统器官(P<0.05);不良反应涉及的药物包括生脉注射液15例(17.44%),双黄连注射液10例(11.63%),清开灵注射液10例(11.63%),参附注射液10例(11.63%),血必净注射液10例(11.63%),醒脑静注射液10例(11.63%),复方丹参注射液6例(6.98%),疏血通注射液5例(5.81%),参麦注射液5例(5.81%),黄芪注射液5例(5.81%)。结论中药注射剂静脉滴注可引发不良反应,临床应严格掌握药品适应证,重视患者个体差异,并规范药品说明书,以提高用药安全。
Objective To investigate the causes and preventive measures of adverse reactions caused by intravenous infusion of traditional Chinese medicine injection. Methods A total of 86 adverse reactions caused by intravenous drip of traditional Chinese medicine injections were reported in the databases of CNKI, Wanfang and Vipu from 2012 to 2014 in Xinhua County People’s Hospital. example. Retrospective analysis of the general situation of patients and adverse reactions. Results The adverse reactions caused by intravenous drip of traditional Chinese medicine injection in this group mainly involved the skin and its appendages, accounting for a higher proportion than other systemic organs (P <0.05). The drugs involved in adverse reactions included Shengmai Injection (15 cases, 17.44%), 10 cases (11.63%) with Shuanghuanglian injection, 10 cases (11.63%) with Qingkailing injection, 10 cases with Shenfu injection (11.63%), 10 cases with Xuebijing injection (11.63% Injection of 10 cases (11.63%), compound Danshen injection in 6 cases (6.98%), Shuxuetong injection in 5 cases (5.81%), Shenmai injection in 5 cases (5.81%), astragalus injection in 5 cases %). Conclusion Chinese medicine injection intravenous drip can cause adverse reactions, clinical indications should be strictly controlled drugs, pay attention to individual patient differences, and regulate the drug instructions to improve drug safety.