据报道,异博定能使心脏病患者和健康志愿受试者的地高辛稳态血药浓度由60％增加至80％。有关这种相互作用的研究表明,异博定能影响地高辛的代谢和肾排泄。其基本原理是否为药物动力学的相互作用而导致地高辛毒性的危险性增加,目前已对这一机理作了研究。在受试者心律不齐期间采用直接试验的方法,异博定是否增加地高辛的毒性危险尚未得到证实。然而,地高辛可能使心律失常患者细胞内的钠升高和钾的浓度降低。这些 Isoproturine is reported to increase the steady-state plasma digoxin concentration in heart patients and healthy volunteers from 60% to 80%. Studies on this interaction have shown that ibuprofen can affect digoxin metabolism and renal excretion. Whether its rationale is pharmacokinetic interactions that increase the risk of digoxin toxicity has been studied for this mechanism. The risk of digoxin toxicity has increased if ibuprofen is used as a direct test during arrhythmias in subjects. However, digoxin may cause elevated intracellular sodium levels and decreased potassium levels in patients with arrhythmias. These ones