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茶碱制剂是治疗支气管痉挛最常见的药物。血清茶碱浓度的有效范围是10～20μg/ml。实际上,所有茶碱浓度大于30μg/ml的病人都有某些中毒症状,常见的是心动过速,恶心、焦虑,严重者可伴有快速性心律失常、癫痫发作、休克和死亡。茶碱中毒的治疗,包括撤除致病因子,治疗并发症,口服活性炭(OAC),严重者可行炭血灌注以提高茶碱的廓清率。作者报道14例血清茶碱浓度大于30μg/ml并具有中毒症状的病人,平均年龄52.3±20.5岁,男8女6,能耐受OAC为Ⅰ组,有10人;不能耐受者为Ⅱ组,有
Theophylline preparations are the most common drugs for the treatment of bronchospasm. The effective range of serum theophylline concentration is 10 ~ 20μg / ml. In fact, all patients with a theophylline concentration above 30 μg / ml have some symptoms of poisoning. Tachycardia, nausea, and anxiety are common. Severe cases may have tachyarrhythmia, seizures, shock, and death. Theophylline poisoning treatment, including the removal of pathogenic factors, the treatment of complications, oral activated carbon (OAC), severe carbon black blood perfusion in order to improve the clearance rate of theophylline. The authors reported 14 patients with serum theophylline concentration greater than 30μg / ml and symptoms of poisoning, the average age of 52.3 ± 20.5 years, 8 males and 6 females, tolerate OAC as group Ⅰ, 10; those who can not tolerate Ⅱ ,Have