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我们首次在国内提纯了光感受器间维生素 A类结合蛋白(interphotoreceptor retinoid-binding protein,IRBP),将其免疫 Lewis 大鼠后动态测定了鼠血清抗IRBP 抗体和抗视网膜 S 抗原抗体.发现抗 IRBP 抗体于免疫后第7天出现,以后逐渐上升,于第26天达高峰,未测出抗 S 抗原抗体.根据特异性抗体与实验性自身免疫性葡萄膜视网膜炎(experimental autoimmune uveoretinitis,EAU)之间的关系,讨论了特异性体液免疫反应在 EAU发生中的作用.
For the first time, we purified the IRP of photoreceptors in vivo and immunized Lewis rats with anti-IRBP antibody and anti-retinal S antigen antibody.It was found that anti-IRBP antibody Appeared on the 7th day after immunization and then gradually increased and reached its peak on the 26th day, no anti-S antigen antibody was detected.According to the results of the correlation between the specific antibody and experimental autoimmune uveoretinitis (EAU) The role of specific humoral immune responses in the development of EAU was discussed.