急性肾损伤(acute kidney injury,AKI),亦称为急性肾衰竭(acute renal failure,ARF),是危急重症住院患者常见的并发症。由于其发病率日趋增高,随之发展为慢性肾脏病乃至终末期肾脏病不断增加,增加了死亡风险,已成为肾科、重症监护医师极具挑战的重要医学课题[1,2]。休克,败血症,器官移植,心血管科及造影剂、化疗、抗生素、中草药等药物,诸因素已成为参与、促使AKI发生发展的主要原因[3]。AKI发病机制复杂,尚不明确。目前研究发现除与肾毒性、缺血缺氧、肾小球血流动力学 Acute kidney injury (AKI), also known as acute renal failure (ARF), is a common complication of critically ill hospitalized patients. Due to its increasing incidence, the subsequent development of chronic kidney disease and end-stage renal disease continue to increase, increasing the risk of death, has become a kidney disease, intensive care physicians challenging the important medical issues [1,2]. Shock, sepsis, organ transplantation, cardiovascular and contrast agents, chemotherapy, antibiotics, herbs and other drugs, the factors that have become involved, to promote the development of AKI [3]. The pathogenesis of AKI is complex and not yet clear. The current study found that in addition to renal toxicity, ischemia and hypoxia, glomerular hemodynamics