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用光镜、电镜和扫描图像分析仪,对比观察静脉注射与肿瘤局部注射血卟啉衍生物并光照,小鼠皮下型H_(22)肝癌细胞的形态学和DNA含量的改变。结果显示,两种给药法并光照对瘤细胞均有杀伤效应,后者更为显著。本实验为治疗某些体表肿瘤采用局部注药光照法,减少全身用药量和毒副作用提供了形态学依据。
The morphology and DNA content of subcutaneous H_(22) hepatocarcinoma cells were observed by light microscope, electron microscope and scanning image analyzer. The results showed that both doses and light irradiation had a killing effect on tumor cells, the latter being more pronounced. This experiment provides morphological basis for the treatment of some body surface tumors with local injection of light, reducing the amount of systemic drugs and side effects.