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为增加瘤段骨灭活的彻底性，缩短其手术灭活时间，并实施手术前后多种有效药物的个案化疗，而进行了瘤段骨超声灭活再植保肢手术与瘤细胞培养敏感药物个案化疗治疗骨肉瘤临床前瞻性随机对照研究。结果表明，观察组瘤段骨术中灭活时间明显缩短（约２０ｍｉｎ），随访期内（平均２．５ａ）无瘤生存率（６６．７％）高于对照组（手术前后固定方案非选择性化疗加单纯酒精灭活再植术）（２３．５％；Ｐ＜０．０５）。其术后合并症、局部复发及转移或死亡的发生率较对照组减低，但无统计学差异（Ｐ＞０．０５）；术后患肢功能评定结果两组间无差异。提示瘤段骨超声灭活再植保肢手术与瘤细胞培养敏感药物个案化疗，是一种方法简便、疗效较好、经济节俭行之有效的方法之一。
In order to increase the thoroughness of tumor bone inactivation, shorten the time of its surgical inactivation, and perform several cases of effective chemotherapy before and after surgery, ultrasound-inactivated limb bone replantation and limb cell surgery and tumor cell culture sensitive drug cases were performed. Clinical prospective randomized controlled study of chemotherapy for osteosarcoma. The results showed that the inactivation time in the observation group was significantly shortened (about 20min). During the follow-up period (average 2.5a), the disease-free survival rate (66.7%) was higher than that in the control group (fixed and non-selected before and after surgery Chemotherapy plus alcohol inactivated replantation (23.5%; P < 0.05). The incidence of postoperative complications, local recurrence and metastasis or death was lower than that of the control group, but there was no statistical difference (P>0.05). There was no difference between the two groups in postoperative limb function assessment results. It is suggested that the ultrasound inactivation of tumor segment bone and replantation of limb salvage operation and the chemotherapy of tumor cell culture sensitive drug case is one of the methods with simple method, good curative effect and economical efficiency.