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近年来,随着生物学的迅速发展,遗传学在各门学科中进展尤较突出。遗传学作为医学的基础学科,对疾病的诊断、治疗和预防意义十分重要。本文就遗传学进展与职业病预防的几个主要方面综述如下。一、生态遗传学1.慢乙酰化肝内 N-乙酰基转移酶活性受单基因的影响,该基因的差异使机体对许多重要的药物(如异烟肼等)的代谢,表现为慢乙酰化型或快乙酰化型。慢乙酰化型因血中药物浓度增加,常发生副作用。在职业病方面,已知
In recent years, with the rapid development of biology, genetics has progressed more prominently in various disciplines. Genetics, as the basic science of medicine, is very important for the diagnosis, treatment and prevention of diseases. This article summarizes several major aspects of genetic advancement and occupational disease prevention as follows. I. Ecological genetics 1. Slow acetylation The activity of N-acetyltransferase in the liver is affected by single genes. The difference in this gene allows the body to metabolize many important drugs (such as isoniazid, etc.) and manifests itself as slow acetylation. Type or fast acetylation type. The slow acetylation type often causes side effects due to an increase in drug concentration in the blood. In occupational diseases, known