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观察了AC1和AC3对抗亚硒酸钠性白内障形成过程中晶状体的脂类过氧化作用,非蛋白质疏基水平及硒含量。结果表明,亚硒酸钠组大鼠,在晶状体混浊出现前已发生脂类过氧化作用及硒含量的明显增加,非蛋白质巯基含量的显著降低,并持续至核混浊期;而同时接受AC1或AC3的大鼠,晶状体非蛋白质巯基水平初期降低,然后逐渐恢复至正常。AC1可有效的对抗亚硒酸钠所致的脂类过氧化作用增加,而AC3的对抗效应需一定剂量及时程,两者对晶状体硒含量均无明显影响。
The effects of AC1 and AC3 on lipid peroxidation, non-protein sparse matrix and selenium content in lens during the formation of sodium selenite cataract were observed. The results showed that lipid peroxidation and selenium content of sodium selenite group rats before the onset of lens opacity were significantly increased, and the content of non-protein sulfhydryl group decreased significantly, and continued to the nuclear opacity period; while AC1 or AC3 rats, lens non-protein sulfhydryl levels initially decreased, and then gradually returned to normal. AC1 can effectively counteract the increase of lipid peroxidation induced by sodium selenite, while the antagonistic effect of AC3 requires a certain dose and time course, and both have no significant effect on the selenium content of lens.