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目的探讨血液灌流治疗急性重度有机磷农药中毒(acute severe organophosphorous pesticide poisoning)的效果。方法2009年08月～2012年12月我科收治急性重度有机磷农药40例，对在常规内科治疗上加用血液灌流治疗的21例作为治疗组，对仅给予常规内科治疗的19例作为对照组。结果治疗组和对照组比较，患者昏迷至清醒时间、胆碱酯酶活力恢复时间、住院时间明显缩短，中间综合征发生率下降，应用阿托品总量减少(P均<0．01)，病死率降低(P<0．05)。结论血液灌流能迅速清除体内毒物，可提高急性重度有机磷农药中毒患者抢救成功率。“,”Objective To evaluate the hemoperfusion treatment of acute severe organophosphorus pesticide poisoning (acute severe organophosphorous pesticide poisoning). Methods from August 2009 to December 2012, our department treated 40 cases of acute severe organophosphorus pesticide, in conventional medical treatment with hemoperfusion treatment of 21 cases as treatment group,for only given conventional medical treatment 19 cases as control group. Results In comparison with control group, patients in treatment group needed shorter time for waking from coma, shorter recovery time of cholinesterase activity and shorter time for hospitalization, and intermediate syndrome incidence decline in this group were reduced (P<0.01). Moreover ,total dose of atropine applied in treatment group were lower (P<0.01), and fatality rate were lower in this group (P<0.05). Conclusion the hemoperfusion can quickly remove toxins in the body and can improve the rescue success rate in patients with acute severe organophosphorus pesticide poisoning.