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目的了解肺结核合并下呼吸道细菌感染病原菌分布和耐药情况。方法对本院2006年2月至2008年10月住院患者送检的合格痰标本进行细菌培养,并对其中141例阳性标本中的169株细菌进行鉴定及药敏试验。结果肺结核合并下呼吸道细菌感染的病原菌中革兰阴性菌居首位(60.4%),依次为真菌(34.3%),革兰阳性菌(15.3%)。革兰阴性杆菌对亚胺培南的敏感性最高,对氨苄西林、哌拉西林等常用抗生素都有不同程度的耐药;革兰阳性球菌对青霉素的耐药性最高,对万古霉素最敏感。结论肺结核合并下呼吸道细菌感染以及耐药情况严重,建议及时对肺结核患者进行痰细菌培养,并根据结果合理选择抗生素。
Objective To understand the distribution and drug resistance of pathogenic bacteria in lower respiratory tract infection complicated by pulmonary tuberculosis. Methods The qualified sputum samples of inpatients admitted from February 2006 to October 2008 in our hospital were cultured and 169 strains of bacteria in 141 positive samples were identified and drug sensitive test. Results Gram-negative bacteria were the most common pathogens (60.4%) in pulmonary tuberculosis with lower respiratory tract bacterial infections, followed by fungi (34.3%) and Gram-positive bacteria (15.3%). Gram-negative bacilli have the highest sensitivity to imipenem, and have different degrees of resistance to commonly used antibiotics such as ampicillin and piperacillin. Gram-positive cocci have the highest resistance to penicillin and the most sensitive to vancomycin . Conclusion Pulmonary tuberculosis with lower respiratory tract bacterial infections and drug resistance is serious, it is recommended that patients with tuberculosis sputum bacterial culture in a timely manner, and based on the results of a reasonable choice of antibiotics.