轮状病毒是引起全世界儿童严重脱水腹泻并导致死亡的重要原因，作者对减毒轮状病毒８９－１２疫苗（以下简称８９－１２疫苗）的安全性、免疫原性和效果进行了评估。 方法这项预期性双盲、安慰剂对照试验于１９９７年８月～１９９８年６月在美国四个中心２１５例健康婴儿中进行 Rotavirus is a major cause of severe dehydration and diarrhea in children around the world, leading to death. The authors evaluated the safety, immunogenicity and efficacy of attenuated rotavirus 89-12 vaccine (hereinafter referred to as 89-12 vaccine). METHODS: This prospective, double-blind, placebo-controlled trial was conducted in 215 healthy infants at four centers in the United States from August 1997 to June 1998