用胆碱能M受体阻断剂,或切除迷走神经,或人为地造成迷走神经兴奋或给予外源性胆碱能药物,均可证实迷走神经对胃泌素释放有抑制作用。这种作用不是继发于迷走神经作用去除后胃肠功能的改变,而是迷走神经的直接作用。这种抑制性纤维存在于迷走神经的胃底分支内,它通过胆碱能或非胆碱能对阿托品敏感的物质发挥作用。在正常情况下,这一抑制性通路有一定的紧张性活动。 Cholinergic M receptor blockers, or excision of the vagus nerve, or artificially induced vagal nerve stimulation or the administration of exogenous cholinergic drugs, may confirm that the vagus nerve inhibits gastrin release. This effect is not secondary to the removal of the vagus nerve function after gastrointestinal changes, but the direct effect of the vagus nerve. This suppressive fiber resides in the gastric fundus branch of the vagus nerve and acts on atropine-sensitive substances, either cholinergic or non-cholinergic. Under normal circumstances, this inhibitory pathway has some tense activity.